Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 3.075


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7



Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_41579325 13.923


chr7_-_96471544 12.638 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr6_+_105511615 10.361 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr8_-_114518194 9.889 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr1_-_214963279 8.227 NM_001438
ESRRG
estrogen-related receptor gamma
chr5_+_170668892 8.176 NM_021025
TLX3
T-cell leukemia homeobox 3
chr18_-_28606839 7.504 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr14_+_75907442 6.993 NM_004452
ESRRB
estrogen-related receptor beta
chr2_-_200033445 6.891 SATB2
SATB homeobox 2
chr13_-_45323757 6.649 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr10_+_83627422 6.573 NM_001165973
NRG3
neuregulin 3
chr1_-_188713324 6.371 NM_199051
FAM5C
family with sequence similarity 5, member C
chr14_-_94306104 6.249 NM_173849
GSC
goosecoid homeobox
chr13_-_101852028 5.974 NM_175929
FGF14
fibroblast growth factor 14
chr16_-_49742651 5.922 NM_002968
SALL1
sal-like 1 (Drosophila)
chr12_+_79625538 5.828 NM_002469
MYF6
myogenic factor 6 (herculin)
chr12_-_14024187 5.772 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr10_+_68355797 5.766 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr12_-_16652202 5.742 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_61532293 5.579 NM_031914
SYT16
synaptotagmin XVI
chr12_-_23995220 5.548 SOX5
SRY (sex determining region Y)-box 5
chr18_-_39111243 5.428 NM_020783
SYT4
synaptotagmin IV
chr4_-_110443247 5.316 NM_032518
NM_198721
COL25A1

collagen, type XXV, alpha 1

chr12_-_23995109 5.285 SOX5
SRY (sex determining region Y)-box 5
chr11_-_27679617 5.245 NM_170733
BDNF
brain-derived neurotrophic factor
chrX_+_99726445 5.200 NM_022144
TNMD
tenomodulin
chr11_-_27698800 5.200 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr11_-_16380967 5.052 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr3_+_174598937 5.035 NM_014932
NLGN1
neuroligin 1
chr1_+_61642287 4.907 NFIA
nuclear factor I/A
chr2_+_171280182 4.883


chr8_+_104900591 4.878 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr14_-_56346849 4.872 NM_021728
OTX2
orthodenticle homeobox 2
chr3_-_62334229 4.866 NM_018008
FEZF2
FEZ family zinc finger 2
chrX_+_28515479 4.852 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr21_-_38955487 4.850 NM_001136154
NM_004449
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr18_-_55136673 4.837 NM_181654
CPLX4
complexin 4
chr6_+_50894397 4.783 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chrX_-_137649180 4.780 NM_033642
FGF13
fibroblast growth factor 13
chr3_+_35696119 4.701 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr4_-_116254381 4.680 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr9_-_8723893 4.649 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr11_-_84311867 4.588 DLG2
discs, large homolog 2 (Drosophila)
chr2_+_225973845 4.582 NM_020864
KIAA1486
KIAA1486
chr5_-_76970129 4.572 OTP
orthopedia homeobox
chr2_+_171280046 4.542 NM_001003845
SP5
Sp5 transcription factor
chr7_+_28418668 4.498 NM_182898
CREB5
cAMP responsive element binding protein 5
chr13_-_34948758 4.498 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr13_-_83354474 4.458 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr2_+_234490781 4.381 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr11_-_123695302 4.242 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr6_-_101018271 4.122 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr5_-_76970264 4.105 NM_032109
OTP
orthopedia homeobox
chr5_-_95794416 4.067 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr4_+_174688183 4.045 NBLA00301
Nbla00301
chr13_-_83354425 3.994 SLITRK1
SLIT and NTRK-like family, member 1
chr11_+_113280727 3.990 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr4_-_41445693 3.951 NM_003924
PHOX2B
paired-like homeobox 2b
chr12_+_84198015 3.896 NM_006982
ALX1
ALX homeobox 1
chr8_+_65655367 3.875 NM_152414
BHLHE22
basic helix-loop-helix family, member e22
chr6_+_108593907 3.845 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr10_+_118073929 3.841 NM_198515
C10orf96
chromosome 10 open reading frame 96
chr12_+_106692291 3.829 NM_203436
ASCL4
achaete-scute complex homolog 4 (Drosophila)
chr4_-_187114407 3.817 SORBS2
sorbin and SH3 domain containing 2
chr4_-_174687931 3.778 NM_021973
HAND2
heart and neural crest derivatives expressed 2
chr3_-_55489973 3.737 WNT5A
wingless-type MMTV integration site family, member 5A
chr15_+_46285789 3.693 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr20_-_49852353 3.651 NM_020436
SALL4
sal-like 4 (Drosophila)
chr1_+_81544432 3.637 LPHN2
latrophilin 2
chr3_-_79899748 3.632 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr15_+_46271158 3.604 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr6_+_50789215 3.595 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr13_+_34948977 3.588 NBEA
neurobeachin
chr17_-_44047299 3.586 NM_024016
HOXB8
homeobox B8
chr7_+_94377145 3.569 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr7_-_27133163 3.546 NM_153631
HOXA3
homeobox A3
chr12_+_63510481 3.539


chr13_+_34948885 3.446 NBEA
neurobeachin
chr8_+_24354387 3.445 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr3_+_35697432 3.436 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr6_+_100161370 3.418 NM_021620
PRDM13
PR domain containing 13
chr7_+_18296569 3.413 HDAC9
histone deacetylase 9
chr3_+_89239494 3.399 EPHA3
EPH receptor A3
chr4_-_21308415 3.325 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr14_-_60185659 3.314 NM_005982
SIX1
SIX homeobox 1
chr4_-_20914626 3.286 NM_147183
KCNIP4
Kv channel interacting protein 4
chr3_-_57209319 3.257 NM_003865
HESX1
HESX homeobox 1
chr1_+_50348052 3.244 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr3_-_99236520 3.217 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr4_-_41445479 3.196 PHOX2B
paired-like homeobox 2b
chr8_-_72431274 3.184 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr10_-_118887801 3.182 NM_001112704
NM_199131
VAX1

ventral anterior homeobox 1

chr3_+_129124591 3.139 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr4_+_41309690 3.083 LIMCH1
LIM and calponin homology domains 1
chr3_+_149930656 3.054 NM_032049
AGTR1
angiotensin II receptor, type 1
chr2_+_214984705 3.033 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr3_-_115380539 3.011 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr3_+_2528272 3.010 CNTN4
contactin 4
chr1_+_50344550 3.006 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chrX_-_33267646 2.934 NM_000109
DMD
dystrophin
chr5_-_41546384 2.916 NM_001005473
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr4_+_41309482 2.901 LIMCH1
LIM and calponin homology domains 1
chr5_-_22248630 2.889 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr1_+_175406685 2.886 FAM5B
family with sequence similarity 5, member B
chr8_-_93176819 2.867 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr18_-_29882555 2.848 NM_001198549
NOL4
nucleolar protein 4
chr4_-_187114863 2.837 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr18_-_3864252 2.821 DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr17_+_72047709 2.807 NM_001077620
PRCD
progressive rod-cone degeneration
chr4_-_20594645 2.798 KCNIP4
Kv channel interacting protein 4
chr12_-_23993830 2.777 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr11_-_36576352 2.767 NM_000536
RAG2
recombination activating gene 2
chr12_-_16649211 2.764 LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_184480572 2.763 NM_001185149
CLDN24
claudin 24
chr1_+_50347176 2.761 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr18_+_57308754 2.761 NM_031891
CDH20
cadherin 20, type 2
chrX_+_11221453 2.757 NM_001142
NM_182680
NM_182681
AMELX


amelogenin, X-linked


chr1_+_50342168 2.752 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr13_-_52320774 2.751 NM_002590
NM_032949
PCDH8

protocadherin 8

chr11_-_27679175 2.726 NM_001143808
NM_001143809
NM_001143810
NM_001143811
BDNF



brain-derived neurotrophic factor



chr1_+_65503011 2.722 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr6_-_94185780 2.718 NM_004440
EPHA7
EPH receptor A7
chr15_+_56217686 2.706 NM_020980
AQP9
aquaporin 9
chr12_-_16321885 2.682 NM_001170798
SLC15A5
solute carrier family 15, member 5
chr11_-_84312085 2.673 NM_001364
DLG2
discs, large homolog 2 (Drosophila)
chr5_-_88004891 2.660 LOC645323
hypothetical LOC645323
chr3_+_35658852 2.659 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr5_-_58918031 2.657 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_-_19151509 2.645 NM_152898
FERD3L
Fer3-like (Drosophila)
chr14_-_56342097 2.644 NM_172337
OTX2
orthodenticle homeobox 2
chr4_+_41309668 2.644 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr11_+_22316242 2.631 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr18_+_30427279 2.621 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr9_-_72673753 2.610 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr7_-_31347032 2.608 NM_022728
NEUROD6
neurogenic differentiation 6
chrX_+_9391314 2.602 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr11_-_27700180 2.591 NM_170731
BDNF
brain-derived neurotrophic factor
chrX_-_32340291 2.589 NM_004011
NM_004012
DMD

dystrophin

chr3_+_68136056 2.581 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr7_+_18501876 2.555 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr1_+_168898898 2.552 PRRX1
paired related homeobox 1
chr14_-_80934523 2.539 NM_033104
STON2
stonin 2
chrX_+_135558001 2.532 NM_000074
CD40LG
CD40 ligand
chr4_+_114190233 2.524 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr3_+_1109619 2.521 NM_014461
CNTN6
contactin 6
chr11_-_30558495 2.513 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr2_+_211166323 2.512 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr1_+_50347188 2.503 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr7_+_113842470 2.503 FOXP2
forkhead box P2
chr8_-_93176618 2.490 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr3_-_139333813 2.486 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr1_-_195302973 2.464 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr7_-_83116414 2.459 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr4_+_119174947 2.453 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr12_+_40117751 2.452 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chrX_+_82649924 2.448 NM_000307
POU3F4
POU class 3 homeobox 4
chr7_-_36992221 2.443 NM_130442
ELMO1
engulfment and cell motility 1
chr14_-_57030227 2.414 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr1_-_93030538 2.402 NM_005665
EVI5
ecotropic viral integration site 5
chr12_-_10846435 2.394 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr7_+_113842407 2.392 FOXP2
forkhead box P2
chr5_-_1935764 2.390 NM_016358
IRX4
iroquois homeobox 4
chr2_+_137464931 2.383 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr11_-_26700121 2.339 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr18_+_50409387 2.337 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr18_+_53170718 2.335 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr1_-_163680941 2.328 NM_006917
RXRG
retinoid X receptor, gamma
chr3_+_116824840 2.319 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr12_+_84792203 2.276 NM_006183
NTS
neurotensin
chr12_-_16650697 2.275 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_-_91164100 2.273 NM_004929
CALB1
calbindin 1, 28kDa
chr4_-_44348414 2.273 NM_182592
YIPF7
Yip1 domain family, member 7
chr5_-_145232723 2.247 NM_001080516
GRXCR2
glutaredoxin, cysteine rich 2
chr18_-_68683913 2.246 NM_138999
NM_153181
NETO1

neuropilin (NRP) and tolloid (TLL)-like 1

chr13_+_77213295 2.230 NM_144595
SLAIN1
SLAIN motif family, member 1
chr4_+_41395493 2.224 LIMCH1
LIM and calponin homology domains 1
chr12_+_52697160 2.214 HOXC5
HOXC6
homeobox C5
homeobox C6
chr2_-_183095308 2.213 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr6_-_64087806 2.205 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr5_-_134899537 2.195 NM_006161
NEUROG1
neurogenin 1
chr3_-_54937001 2.189 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chr2_-_182253457 2.186 NM_002500
NEUROD1
neurogenic differentiation 1
chr12_+_79362256 2.183 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr4_-_164754106 2.182 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr17_-_30909219 2.178 NM_001129820
SLFN14
schlafen family member 14
chr18_-_30057512 2.169 NM_001198546
NM_001198548
NM_003787
NOL4


nucleolar protein 4


chr3_-_71262426 2.167 FOXP1
forkhead box P1
chr1_+_198263352 2.167 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr7_+_28441758 2.164 NM_004904
CREB5
cAMP responsive element binding protein 5
chr12_-_16650687 2.146 LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_-_100105883 2.140 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr13_-_102517196 2.119 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr4_+_93444572 2.117 NM_001510
GRID2
glutamate receptor, ionotropic, delta 2
chr7_-_72676750 2.104 NM_032951
NM_032952
NM_032953
NM_032954
MLXIPL



MLX interacting protein-like



chr11_-_31782169 2.104 PAX6
paired box 6
chr18_+_74841262 2.099 NM_171999
SALL3
sal-like 3 (Drosophila)
chr4_+_114433551 2.076 ANK2
ankyrin 2, neuronal
chr11_-_128217550 2.056 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr1_-_214663360 2.055 NM_007123
NM_206933
USH2A

Usher syndrome 2A (autosomal recessive, mild)

chr3_-_71376919 2.044 FOXP1
forkhead box P1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.03 8.10e-30 GO:0032501 multicellular organismal process
2.39 2.93e-28 GO:0007275 multicellular organismal development
2.60 4.35e-28 GO:0048731 system development
2.29 4.80e-28 GO:0032502 developmental process
2.47 8.62e-28 GO:0048856 anatomical structure development
3.23 8.15e-23 GO:0007399 nervous system development
2.79 1.95e-20 GO:0048513 organ development
2.43 9.98e-15 GO:0030154 cell differentiation
2.37 6.92e-14 GO:0048869 cellular developmental process
2.70 7.88e-14 GO:0009653 anatomical structure morphogenesis
4.30 1.89e-13 GO:0007417 central nervous system development
3.28 2.45e-13 GO:0022008 neurogenesis
3.31 1.03e-12 GO:0048699 generation of neurons
3.52 1.16e-11 GO:0009790 embryo development
2.18 6.17e-11 GO:0006355 regulation of transcription, DNA-dependent
5.20 8.12e-11 GO:0007423 sensory organ development
4.53 1.20e-10 GO:0048598 embryonic morphogenesis
7.15 1.89e-10 GO:0045165 cell fate commitment
2.91 2.93e-10 GO:0006357 regulation of transcription from RNA polymerase II promoter
3.58 2.98e-10 GO:0009887 organ morphogenesis
2.10 6.36e-10 GO:0051252 regulation of RNA metabolic process
3.21 6.98e-10 GO:0010557 positive regulation of macromolecule biosynthetic process
2.02 1.71e-09 GO:0010556 regulation of macromolecule biosynthetic process
4.36 1.86e-09 GO:0007420 brain development
3.23 3.16e-09 GO:0030182 neuron differentiation
3.37 4.45e-09 GO:0045893 positive regulation of transcription, DNA-dependent
6.51 4.50e-09 GO:0048562 embryonic organ morphogenesis
6.15 4.89e-09 GO:0030900 forebrain development
4.33 1.11e-08 GO:0007389 pattern specification process
2.90 1.12e-08 GO:0009888 tissue development
1.99 1.26e-08 GO:2000112 regulation of cellular macromolecule biosynthetic process
3.18 1.66e-08 GO:0010628 positive regulation of gene expression
3.03 1.78e-08 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
14.70 1.83e-08 GO:0021536 diencephalon development
2.87 2.73e-08 GO:0009891 positive regulation of biosynthetic process
3.14 4.45e-08 GO:0051254 positive regulation of RNA metabolic process
2.94 5.04e-08 GO:0051173 positive regulation of nitrogen compound metabolic process
5.01 5.44e-08 GO:0048568 embryonic organ development
3.58 1.08e-07 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.87 1.15e-07 GO:0009889 regulation of biosynthetic process
1.90 1.38e-07 GO:0010468 regulation of gene expression
2.80 1.64e-07 GO:0031328 positive regulation of cellular biosynthetic process
1.86 3.08e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.86 3.08e-07 GO:0031326 regulation of cellular biosynthetic process
2.66 3.88e-07 GO:0048468 cell development
6.88 5.80e-07 GO:0043583 ear development
4.60 7.98e-07 GO:0050767 regulation of neurogenesis
2.82 8.10e-07 GO:0007267 cell-cell signaling
2.95 9.26e-07 GO:0045595 regulation of cell differentiation
1.80 1.65e-06 GO:0051171 regulation of nitrogen compound metabolic process
4.57 2.12e-06 GO:0003002 regionalization
3.71 2.13e-06 GO:0009792 embryo development ending in birth or egg hatching
16.54 2.15e-06 GO:0021983 pituitary gland development
8.02 2.64e-06 GO:0042471 ear morphogenesis
5.44 3.22e-06 GO:0009952 anterior/posterior pattern formation
3.43 3.83e-06 GO:0032583 regulation of gene-specific transcription
3.90 5.37e-06 GO:0060284 regulation of cell development
3.62 6.95e-06 GO:0043009 chordate embryonic development
4.09 8.74e-06 GO:0051960 regulation of nervous system development
2.29 1.47e-05 GO:0010604 positive regulation of macromolecule metabolic process
2.47 2.17e-05 GO:0050793 regulation of developmental process
6.79 2.52e-05 GO:0048839 inner ear development
2.14 2.60e-05 GO:0050877 neurological system process
2.37 2.75e-05 GO:0007154 cell communication
7.26 3.58e-05 GO:0048706 embryonic skeletal system development
1.37 3.91e-05 GO:0050794 regulation of cellular process
1.97 5.02e-05 GO:0003008 system process
1.62 6.98e-05 GO:0060255 regulation of macromolecule metabolic process
2.14 8.31e-05 GO:0051239 regulation of multicellular organismal process
3.41 8.91e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
2.14 1.07e-04 GO:0009893 positive regulation of metabolic process
4.75 1.77e-04 GO:0001654 eye development
2.14 2.47e-04 GO:0031325 positive regulation of cellular metabolic process
1.31 2.87e-04 GO:0065007 biological regulation
7.47 3.24e-04 GO:0042472 inner ear morphogenesis
2.47 4.17e-04 GO:2000026 regulation of multicellular organismal development
4.18 5.22e-04 GO:0045664 regulation of neuron differentiation
1.32 6.26e-04 GO:0050789 regulation of biological process
2.93 6.35e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.69 1.04e-03 GO:0048522 positive regulation of cellular process
4.15 1.25e-03 GO:0048732 gland development
3.60 1.29e-03 GO:0045596 negative regulation of cell differentiation
3.93 1.29e-03 GO:0043193 positive regulation of gene-specific transcription
3.03 1.44e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
3.29 1.69e-03 GO:0001501 skeletal system development
11.88 2.04e-03 GO:0031128 developmental induction
11.88 2.04e-03 GO:0045168 cell-cell signaling involved in cell fate commitment
2.73 2.59e-03 GO:0000904 cell morphogenesis involved in differentiation
2.24 2.67e-03 GO:0006351 transcription, DNA-dependent
4.13 2.78e-03 GO:0035270 endocrine system development
7.79 2.91e-03 GO:0070848 response to growth factor stimulus
3.41 3.06e-03 GO:0035295 tube development
1.51 3.55e-03 GO:0080090 regulation of primary metabolic process
2.81 3.68e-03 GO:0051094 positive regulation of developmental process
1.51 3.90e-03 GO:0031323 regulation of cellular metabolic process
1.60 5.88e-03 GO:0048518 positive regulation of biological process
4.63 7.43e-03 GO:0043010 camera-type eye development
3.09 8.04e-03 GO:0051093 negative regulation of developmental process
8.02 8.69e-03 GO:0048663 neuron fate commitment
2.56 8.86e-03 GO:0045892 negative regulation of transcription, DNA-dependent
6.85 8.87e-03 GO:0048704 embryonic skeletal system morphogenesis
2.45 9.51e-03 GO:0000902 cell morphogenesis
3.28 9.82e-03 GO:0048534 hemopoietic or lymphoid organ development
2.40 1.02e-02 GO:0032989 cellular component morphogenesis
2.51 1.30e-02 GO:0051253 negative regulation of RNA metabolic process
1.44 1.62e-02 GO:0019222 regulation of metabolic process
8.82 1.75e-02 GO:0071363 cellular response to growth factor stimulus
5.59 1.76e-02 GO:0048592 eye morphogenesis
2.03 2.14e-02 GO:0009605 response to external stimulus
3.04 2.86e-02 GO:0002520 immune system development
2.35 2.95e-02 GO:0010629 negative regulation of gene expression
3.60 3.10e-02 GO:0007517 muscle organ development
2.02 3.11e-02 GO:0032774 RNA biosynthetic process
2.38 3.33e-02 GO:0048666 neuron development
4.01 3.52e-02 GO:0060562 epithelial tube morphogenesis
9.80 3.99e-02 GO:0048286 lung alveolus development
4.58 4.40e-02 GO:0072001 renal system development
5.59 4.79e-02 GO:2000027 regulation of organ morphogenesis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.08 4.87e-05 GO:0045202 synapse
3.38 1.35e-04 GO:0044456 synapse part
4.47 2.73e-04 GO:0045211 postsynaptic membrane
1.69 4.16e-04 GO:0044459 plasma membrane part
2.48 4.55e-04 GO:0030054 cell junction
1.41 3.17e-03 GO:0005886 plasma membrane
1.40 3.91e-03 GO:0071944 cell periphery
2.92 2.65e-02 GO:0005667 transcription factor complex
2.41 3.79e-02 GO:0043005 neuron projection

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.63 2.50e-24 GO:0043565 sequence-specific DNA binding
3.73 1.91e-22 GO:0001071 nucleic acid binding transcription factor activity
3.73 1.91e-22 GO:0003700 sequence-specific DNA binding transcription factor activity
3.52 6.26e-20 GO:0030528 transcription regulator activity
1.96 7.69e-09 GO:0003677 DNA binding
4.37 1.11e-05 GO:0000975 regulatory region DNA binding
4.37 1.11e-05 GO:0001067 regulatory region nucleic acid binding
4.37 1.11e-05 GO:0044212 transcription regulatory region DNA binding
3.56 1.37e-05 GO:0016563 transcription activator activity
4.12 1.41e-05 GO:0046982 protein heterodimerization activity
3.87 6.58e-04 GO:0010843 promoter binding
3.09 1.61e-03 GO:0016564 transcription repressor activity
1.48 3.93e-03 GO:0003676 nucleic acid binding
2.28 4.04e-03 GO:0046983 protein dimerization activity
4.24 8.43e-03 GO:0015276 ligand-gated ion channel activity
4.24 8.43e-03 GO:0022834 ligand-gated channel activity
26.47 3.47e-02 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
26.47 3.47e-02 GO:0001012 RNA polymerase II regulatory region DNA binding
6.06 4.42e-02 GO:0003707 steroid hormone receptor activity